The Implementation Support Unit (ISU) was established within the Geneva Branch of the United Nations Office for Disarmament Affairs by the Sixth Review Conference in 2006. The ISU provides administrative support to meetings agreed by the Review Conference as well as the comprehensive implementation and universalization of the Convention and the exchange of confidence-building measures.

The mandate of the ISU has been renewed by each subsequent Review Conference. Most recently, at the Ninth Review Conference in 2022, States Parties renewed the mandate of the ISU until 2027.